To block a website based on a custom list, the customer should add the websites to a blocked type destination list. A destination list is a custom list of domains or URLs that the customer wants to allow or block for their identities. The customer can create destination lists through the Policy Components > Destination Lists page, or within the policy wizard when creating or editing a policy. The custom URL destination block lists feature enables Umbrella to extend a domain level block list to encompass full and partial URLs. In turn, this allows the customer to block certain portions of a website based specifically on the full or partial URL. This feature requires the customer to enable the intelligent proxy and install a root certificate for SSL decryption. References:
* Configure Web Policies and Destination Lists - Cisco Umbrella
* Control Access to Custom URLs - Umbrella SIG User Guide
* Cisco 350-701: How should customer block websites based on custom list
* Umbrella Dashboard: New Features-Custom blocked URLs
* Understanding Destination lists supported entries and ... - Cisco Umbrella

Cisco Cloudlock: Secure your cloud users, data, and applications with the cloud-native Cloud Access Security Broker (CASB) and cloud cybersecurity platform.
Reference:
738565.pdf

ISE posture assessment allows you to inspect the security "health" of your PC and MAC clients. This includes checking for the installation, running state, and last update for security software, such as anti-virus, anti-malware, personal firewall, and so on1. Windows service and Windows firewall are examples of such security software that can be checked by ISE posture assessment. Computer identity and user identity are not conditions that can be checked by ISE posture assessment, as they are related to authentication and authorization, not security posture. Default browser is also not a condition that can be checked by ISE posture assessment, as it is not a security software or a security risk. References: 1: Chapter 15. Device Posture Assessment - Cisco ISE for BYOD and Secure Unified Access, 3