In Active-backup mode, one network interface is active while the other is in standby mode. If the active interface fails, the standby interface takes over, providing seamless failover without any disruption to user VMs. In this case, since the cluster has two 10 GbE ports on each node, and only one link has failed, the user VMs will continue to operate normally using the second link.

Data Protection is a feature that ensures that data stored on a VM is protected against data loss in the event of hardware failure, data corruption, or other unexpected events. It typically includes features such as snapshots, replication, and backup, which enable administrators to create multiple copies of data and store them in different locations to provide redundancy and ensure availability.
Replication Factor is a related concept, but it is not a VM-level feature in and of itself. Replication Factor is a setting that can be configured at the storage level to determine how many copies of data are stored on different nodes in a distributed storage system. Data Locality and Deduplication are also related concepts, but they do not directly ensure continuous availability of data.

Genesis is an AHV feature that proactively monitors a Nutanix cluster for compute and storage I/O contention or hotspots over a period of time. It can detect and alert administrators to any issues related to resource utilization and contention, allowing them to take proactive steps to resolve any issues before they become larger problems. Reference: https://portal.nutanix.com/page/documents/details?targetId=Platform-Administrator-Guide-v5_7:pag-ahv-genesis-c.html

Replication Factor is configured on a Container entity. Containers group together virtual disks and files, and allow administrators to set policies on a group level. This allows for increased flexibility in managing storage resources and allows administrators to easily set policies across multiple virtual disks and files.
Replication Factor is configured on Containers. A container is a logical grouping of one or more storage pools and defines the storage resources available to virtual machines. The replication factor is a setting that determines the number of copies of data that are stored across the cluster. By configuring the replication factor on a container, you are setting the number of copies of data that will be stored for all virtual machines that are associated with that container.
For example, if you have a container with a replication factor of 3, it means that three copies of data will be stored across the cluster, and two copies are required to reconstruct the data in case of a failure.

Run cluster efficiency summary report selecting all the VMs that constitute the applications. Running a cluster efficiency summary report selecting all the VMs that constitute the application will allow the administrator to understand if workloads, historically, have been evenly distributed across these VMs. This report will provide information about the average and peak memory usage for each of the VMs. Reference: https://portal.nutanix.com/page/documents/details?targetId=Platform-Administrator-Guide-v5_7:pag-cluster-efficiency-report-c.html