Explanation
VMware Horizon Cloud on Microsoft Azure is the only deployment solution that meets all the requirements. VMware Horizon Cloud on Microsoft Azure supports Windows 10 Enterprise multi-session desktops, which are a new Remote Desktop Session Host exclusive to Azure Virtual Desktop on Azure1. It also supports App Volumes, which is a real-time application delivery system that enables IT to instantly provision applications to users or desktops. VMware Horizon Cloud on Microsoft Azure supports centralized brokering, which means that the Horizon Cloud Service acts as a single point of entry for end users to access their virtual desktops and applications. VMware Horizon Cloud on Microsoft Azure also supports automatic routing of end-users to the most appropriate virtual workspace, using the Universal Broker feature. Universal Broker is a cloud-based brokering service that provides a unified user experience across multiple Horizon pods and clouds.
VMware vSphere Desktop Edition does not support Windows 10 Enterprise multi-session desktops, as they are only available on Azure Virtual Desktop1. VMware Workspace ONE Unified Endpoint Management does not support App Volumes, as it is a different solution for managing devices and applications. VMware Horizon On-Premises does not support automatic routing of end-users to the most appropriate virtual workspace, as it requires manual configuration of load balancing and global entitlements. References:
Profile production applications in Azure with Application Insights Profiler1 Using Application Profiler - VMware Docs2 First look at profiling tools - Visual Studio (Windows)3 App Volumes Overview Horizon Cloud Service on Microsoft Azure Architecture Universal Broker Overview Workspace ONE UEM Overview Load Balancing Across Pods and Sites in a Cloud Pod Architecture Environment

VMware Blast policy settings are stored in the registry key HKLM\Software\Policies\VMware, Inc.\VMware Blast\Config on the remote desktops or RDS hosts that use the VMware Blast display protocol. These settings can be configured by using the VMware Blast ADMX template file (vdm_blast.admx) and applying it through Microsoft Group Policy Object (GPO). Some of these settings can be changed in real time, which means that they take effect immediately after the policy is applied, without requiring a reboot or a reconnection of the Horizon Client. However, some of these settings cannot be changed in real time, which means that they require a reboot or a reconnection of the Horizon Client to take effect.
The effect of changing any VMware Blast policy that cannot be changed in real time is that the Microsoft GPO update rules apply and GPOs are updated manually or by restarting the Horizon Agent. This means that the new policy settings will not be applied until one of the following events occurs:
The Horizon Agent service is restarted on the remote desktop or RDS host. This can be done manually by using the Services console or the command-line tool sc.exe, or automatically by using a scheduled task or a script.
The remote desktop or RDS host is rebooted. This can be done manually by using the Restart option in Windows, or automatically by using a scheduled task or a script.
The Group Policy refresh interval is reached. This is a configurable time interval that determines how often the system checks for and applies new or changed GPOs. By default, this interval is 90 minutes for domain members and 5 minutes for domain controllers, with a random offset of 0 to 30 minutes. This interval can be modified by using the Group Policy refresh interval for computers setting in the Computer Configuration\Administrative Templates\System\Group Policy folder of the Group Policy Management Console.
Therefore, to ensure that the VMware Blast policy settings that cannot be changed in real time are applied as soon as possible, it is recommended to restart the Horizon Agent service or reboot the remote desktop or RDS host after applying the policy.
References: VMware Blast Policy Settings, Group Policy refresh intervals, and [VMware Horizon 8.x Professional Course]

Unified Access Gateway (UAG) is a secure gateway appliance that provides access to VMware Horizon based resources such as virtual desktops, RDSH-based applications, and physical Windows machines. UAG supports multiple authentication methods and protocols, such as SAML, OAuth, and RADIUS, to provide secure access to end users from any device and location. UAG also provides edge services such as load balancing, high availability, and firewall rules to optimize the performance and availability of Horizon based resources12. References := 1: VMware Horizon Architecture Planning: Unified Access Gateway 2: VMware Unified Access Gateway Administration Guide: Introduction to Unified Access Gateway

Windows golden image optimization is the process of reducing the size and improving the performance of the Windows OS image that is used as the base for the desktop pools. Some of the best practices for Windows golden image optimization are:
Disable unnecessary services: Services that are not required for the desktop functionality or user experience should be disabled to reduce the resource consumption and potential security risks. For example, services such as Windows Search, Windows Defender, Windows Update, and Superfetch can be disabled for better performance and stability.
Disable power options: Power options such as hibernation and sleep mode should be disabled to free up disk space and avoid potential issues with the desktop state. Hibernation can consume a large amount of disk space by creating a hiberfil.sys file that stores the system memory contents when the desktop is powered off. Sleep mode can cause problems with network connectivity and user sessions when the desktop is resumed from a low-power state.
Other best practices for Windows golden image optimization include:
Activate Windows OS paging: Paging is a mechanism that allows the OS to use a portion of the disk as virtual memory when the physical memory is insufficient. Paging can improve the performance and stability of the desktops by preventing out-of-memory errors and reducing memory contention.
However, paging can also increase disk I/O and wear, so it should be configured with caution and monitored regularly.
Turn off automatic Windows maintenance (scheduled tasks): Automatic Windows maintenance is a feature that runs various tasks such as disk defragmentation, disk cleanup, security scanning, and system diagnostics in the background. These tasks can consume a lot of CPU, memory, and disk resources and interfere with the user experience and desktop performance. Therefore, it is recommended to turn off automatic Windows maintenance and run these tasks manually or on a scheduled basis when the desktops are not in use.
Turn off automatic Windows Updates: Automatic Windows Updates is a feature that downloads and installs updates for the OS and other Microsoft products in the background. These updates can consume bandwidth, disk space, and CPU resources and cause compatibility issues with some applications or drivers. Therefore, it is recommended to turn off automatic Windows Updates and manage the updates manually or through a centralized tool such as VMware Update Manager or Microsoft WSUS.
References: [Optimizing Your VMware Horizon View 7.x Golden Image] and [VMware Horizon 8.x Professional Course]