How To Troubleshoot ISE Failed Authentications & Authorizations
Check the ISE Live Logs
Login to the primary ISE Policy Administration Node (PAN).
Go to Operations > RADIUS > Live Logs
(Optional) If the event is not present in the RADIUS Live Logs, go to Operations > Reports > Reports > Endpoints and Users > RADIUS Authentications Check for Any Failed Authentication Attempts in the Log

Cisco Defense Orchestrator is a cloud-based management solution that allows you to manage security policies and device configurations with ease across multiple Cisco and cloud-native security platforms.
Cisco Defense Orchestrator features:
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Management of hybrid environments: Managing a mix of firewalls running the ASA, FTD, and Meraki MX software is now easy, with the ability to share policy elements across platforms.
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Maybe the "newly installed service" in this Qmentions about Advanced Malware Protection (AMP) which can be used along with ESA. AMP allows superior protection across the attack continuum.
+ File Reputation - captures a fingerprint of each file as it traverses the ESA and sends it to AMP's cloudbased intelligence network for a reputation verdict. Given these results, you can automatically block malicious files and apply administrator-defined policy.
+ File Analysis - provides the ability to analyze unknown files that are traversing the ESA. A highly secure sandbox environment enables AMP to glean precise details about the file's behavior and to combine that data with detailed human and machine analysis to determine the file's threat level. This disposition is then fed into AMP cloud-based intelligence network and used to dynamically update and expand the AMP cloud data set for enhanced protection