The termination phase may be difficult for a client, and they may begin to exhibit a return of symptoms previously resolved. The client may also exhibit provocation and regression in an attempt to continue therapy. These are examples of resistance to termination of therapy.

FXS, also known as Martin-Bell syndrome, is a genetic disorder caused by a mutation in the FMR1 gene on the X chromosome. It is the second most common inherited form of intellectual disability and affects about 1 in 1,000 males and 1 in 2,000 females. It is characterized by intellectual disability and physical characteristics such as a long face, large ears, and large testicles in males.

Risk factors for developing somatic symptom disorder are:
* Female gender
* Lower socioeconomic status
* Unemployment
* Older age
* Fewer years of education
* Recent stressful life events
* Negative affectivity
* Childhood sexual abuse
* Comorbid psychiatric condition
* Perceived illness benefits
* Sensitization to pain
* Heightened attention to bodily sensations

The following common medications can induce depression:
* Beta-blockers such as propranolol
* Steroids
* Interferon
* Isotretinoin
* Some retroviral drugs
* Neoplastic drugs
* Benzodiazepines
* Progesterone
The following medications can induce mania:
* Steroids
* Disulfiram
* Isoniazid
* Antidepressants

Indiscriminate enthusiasm would typically be found during a mental status exam for mania. Goal-directed, overall organized, and redirectable behaviors are common thought processes that manifest with anxiety.