The block IP feature can be configured in two Security Profiles: Vulnerability Protection and Anti-spyware.
The block IP feature allows the firewall to block traffic from a source IP address for a specified period of time after detecting a threat. This feature can help prevent further attacks from the same source and reduce the load on the firewall1. The block IP feature can be enabled in the following Security Profiles:
Vulnerability Protection: A Vulnerability Protection profile defines the actions that the firewall takes to protect against exploits and vulnerabilities in applications and protocols. You can configure a rule in the Vulnerability Protection profile to block IP connections for a specific threat or a group of threats2.
Anti-spyware: An Anti-spyware profile defines the actions that the firewall takes to protect against spyware and command-and-control (C2) traffic. You can configure a rule in the Anti-spyware profile to block IP addresses for a specific spyware or C2 signature.
References: Monitor Blocked IP Addresses, Block IP Addresses, Vulnerability Protection Profile, [Anti- Spyware Profile], Certifications - Palo Alto Networks, [Palo Alto Networks Certified Network Security Administrator (PAN-OS 10.0)] or [Palo Alto Networks Certified Network Security Administrator (PAN-OS
10.0)].

Reference: https://knowledgebase.paloaltonetworks.com/KCSArticleDetail?id=kA10g000000ClVHCA0

https://docs.paloaltonetworks.com/pan-os/9-1/pan-os-web-interface-help/objects/objects-security-profiles
/actions-in-security-profiles

Another reason to choose the Windows agent over the integrated PAN-OS agent is to save processing cycles on the firewall's management plane.