Reference: https://docs.paloaltonetworks.com/pan-os/8-1/pan-os-web-interface-help/objects/objects-security- profiles-vulnerability-protection.html Vulnerability Protection Security Profiles protect against threats entering the network. For example, Vulnerability Protection Security Profiles protect against buffer overflows, illegal code execution, and other attempts to exploit system vulnerabilities. The default Vulnerability Protection Security Profile protects clients and servers from all known critical-, high-, and medium-severity threats. You also can create exceptions that enable you to change the response to a specific signature.

* An Anti-Spyware security profile is a set of rules that defines how the firewall detects and prevents spyware from compromising hosts on the network. Spyware is a type of malware that collects information from the infected system, such as keystrokes, browsing history, or personal data, and sends it to an external command-and-control (C2) server1.
* An Anti-Spyware security profile consists of four tabs: Signature Policies, Signature Exceptions, Machine Learning Policies, and Inline Cloud Analysis1.
* The Signature Policies tab allows you to configure the actions and log settings for each spyware signature category, such as adware, botnet, keylogger, phishing, or worm. You can also enable DNS Security to block malicious DNS queries and responses1.
* The Signature Exceptions tab allows you to create exceptions for specific spyware signatures that you want to override the default action or log settings. For example, you can allow a signature that is normally blocked by the profile, or block a signature that is normally alerted by the profile1.
* The Machine Learning Policies tab allows you to configure the actions and log settings for machine learning based signatures that detect unknown spyware variants. You can also enable WildFire Analysis to submit unknown files to the cloud for further analysis1.
* The Inline Cloud Analysis tab allows you to enable machine learning based engines that detect unknown spyware variants in real time. These engines use cloud-based models to analyze the behavior and characteristics of network traffic and identify malicious patterns. You can enable inline cloud analysis for HTTP/HTTPS traffic, SMTP/SMTPS traffic, or IMAP/IMAPS traffic1.
Therefore, the tab that is used to enable machine learning based engines is the Inline Cloud Analysis tab.
References:
1: Security Profile: Anti-Spyware - Palo Alto Networks

In the Allow FTP to web server rule, FTP is allowed using port based rule and not APP-ID.